LA MS DAY - PROGRAM
9:00 am ● Check in & coffee
9:45 am - 10:00 am ● Opening remarks
10:00-10:15 am ● Lightning Talks (Evosep ● Syft ● Waters)
10:15 am - 10:40 am ● Mario Alba (Doctoral Candidate - University of Southern California)
Hepatic Steatosis Induced by Bioactive Lipids Regulated by AKT Specific Isoforms
10:40 am - 11:05 am ● Dr. Gazmend Elezi (Postdoctoral Scholar - UCLA)
Novel LC-MS Technique for Detecting Ancient Wine Molecules
11:05 am - 11:30 am ● Dr. Anja Karlstaedt (Assistant Professor - Cedars Sinai Medical Center)
Isocitrate Dehydrogenase 1 Regulates Cardiac Metabolic Adaptation During Oncometabolic Stress
11:30 am - 1:00 pm ● Lunch and Poster Session
1:00 pm - 1:10 pm ● Lightning Talks (Agilent ● MOBILion Systems)
1:25 pm - 1:50 pm ● Dr. Chenghao Zhu (Postdoctoral Fellow - UCLA)
moPepGen: Rapid and Comprehensive Elucidation of Novel Proteogenomic Peptides
1:50 pm - 2:15 pm ● Dr. Justyna Fert-Bober (Assistant Professor - Cedars Sinai Medical Center)
High Resolution Ion Mobility to the Rescue for Protein Citrullination Analysis
2:20 pm - 2:30 pm ● Lightning Talks (Bruker ● Thermo Fisher)
2:30 pm - 3:30 pm ● Keynote Speaker ● Dr. Lisa M. Jones (Professor - UCSD)
In-Cell Protein Footprinting Coupled with Mass Spectrometry for Structural Biology Across the Proteome
3:30 pm - 4:30 pm ● Career Panel Q&A
4:30 pm - 5:30 pm ● Networking Happy hour
This is our inaugural LA Mass Spec Day, in collaboration with the University of Southern California, which will take place in person on April 2nd, 2024, at the USC Michaelson Center for Convergent Bioscience.
LA Mass Spec Day serves as a significant platform for networking and education for early-career scientists who are on the cusp of establishing their own research labs or venturing into the pharmaceutical and biotechnology industries. Our one-day symposium, hosted by LAMMS and USC, provides a unique opportunity for applicants to showcase their mass spectrometry-related research.
With an anticipated audience of approximately 75 postdoctoral fellows, alumni, vendors, and participating faculty from universities across the Southern California region, the event promises to facilitate the exchange of ideas and foster collaboration.
Keynote speaker
Dr. Lisa M. Jones
Professor and Chancellor's Associates Endowed Chair in Chemistry and Biochemistry
University of California San Diego, USA
In-Cell Protein Footprinting Coupled with Mass Spectrometry for Structural Biology Across the Proteome
In recent years, protein footprinting coupled with mass spectrometry has been used to identify protein-protein interaction sites and regions of conformational change through modification of solvent accessible sites in proteins. The footprinting method, fast photochemical oxidation of proteins (FPOP), utilizes hydroxyl radicals to modify these solvent accessible sites. To date, FPOP has been used in vitroon relatively pure protein systems. We have further extended the FPOP method for in vivo analysis of proteins. This will allow for study of proteins in their native cellular environment and be especially useful for the study of membrane proteins which can be difficult to purify for in vitro studies. A major application of the in vivomethod is for proteome-wide structural biology. To this end, we have further developed the method for patient samples, specifically peripheral blood mononuclear cells (PBMCs). We have optimized several parameters for labeling of proteins in these patient samples. This method have the potential to become a powerful tool in the structural biology toolbox.
Lisa M. Jones is the Chancellor’s Associate Endowed Chair of Chemistry and Biochemistry at the University of California San Diego. She received her PhD in Chemistry from Georgia State University. She received postdoctoral training in structural virology at the University of Alabama-Birmingham and in MS-based protein footprinting at Washington University in St. Louis. Her research is focused on extending the protein footprinting method fast photochemical oxidation of proteins (FPOP) coupled with mass spectrometry into complex model systems. Her lab has extended the method for in-cell analysis to provide structural information across the proteome. She has further developed the method for in vivo analysis in C. elegans, an animal model for human disease. Her lab aims to understand the biological causes of health disparities in cancer and other diseases. She also has a passion for increasing diversity in STEM and participates in several outreach initiatives to achieve this.